Brain vs. Bone: Does Fracture Fixation Technique Influence Outcomes in Patients with Traumatic Brain Injury?


One of the most common injuries that accompanies traumatic brain injury (TBI) are long bone fractures. The optimal method and timing of long bone fracture fixation is a topic of debate, and even less is known about optimal fracture management in the setting of TBI. This prospective observational multi-center trial through aims to determine whether the type or timing of lower extremity fracture fixation technique influences cognitive outcomes in patients with TBI. The study aims to characterize the progression of TBI based on fracture fixation type, identify treatment strategies in TBI patients with polytrauma, and improve outcomes in TBI patients with long bone fractures.

The Lead Principal Investigator is Dr. Mira Ghneim, University of Maryland Medical Center. Dr. Mark Scott is the Site Principal Investigator. Melissa Harry, PhD, and Dr. Kristin Colling are Site Co-Investigators. 


Principal Investigator(s)
Dr. Kristin Colling, MD

Research Study Categories

  • Adult Studies


  • Trauma
  • Orthopedics
Trauma Research Team at

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