COG AALL1521: A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia

Objective

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optimize the dose of study drug (ruxolitinib) in combination with the chemotherapy regimen. Part 2 will evaluate the efficacy of combination chemotherapy and ruxolitinib at the recommended dose determined in Part 1.

https://clinicaltrials.gov/ct2/show/NCT02723994

Location: Essentia Health Cancer Centers

Research Study Categories

  • Pediatric Studies

Specialty

  • Hematology
Contact
Cancer Clinical Trials at 218-786-3308
or cancertrials@essentiahealth.org

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